Роль эндотелиальных прогениторных клеток в развитии осложнений сахарного диабета

У больных сахарным диабетом (СД) риск развития сердечно-сосудистых заболеваний (ССЗ) в 2?4 раза выше, чем у больных без нарушения углеводного обмена. При СД хроническая гипергликемия запускает ряд патофизиологических механизмов, приводящих к повреждению эндотелия. В настоящее время считается, что в процессе восстановления эндотелия принимают участие циркулирующие клетки-предшественницы, выделяющиеся из костного мозга (КМ). Данные клетки, так называемые эндотелиальные прогениторные клетки (ЭПК), участвуют в поддержании функции эндотелия и способствуют его восстановлению после повреждения, а также образованию новых кровеносных сосудов. Многочисленные литературные данные показывают, что при СД наблюдается снижение количества и нарушение функции ЭПК. Кроме того, у больных СД нарушается адекватная реакция со стороны КМ в ответ на стимулирующие факторы. В данном обзоре рассмотрена роль ЭПК в развитии и прогрессировании микро- и макрососудистых осложнений СД.

сахарный диабет, эндотелиальные прогениторные клетки, осложнения сахарного диабета, сердечно-со- судистые заболевания

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