Quality of ejaculate of male patients with type 2 diabetes mellitus (DM), vaccinated with GamCovidVac (Sputnik V)
https://doi.org/10.14341/DM12775
Abstract
Background: New coronavirus infection (Covid-19) in patients with diabetes type 2 mellitus (DM) often has severe clinical course and manifestation. This comorbidity is a reasonable indication for vaccination. Male patients are often concerned about the vaccination impact on their fertility, so the current research of this issue seems to be essential and relevant.
Aims: To evaluate the quality of ejaculate in type 2 diabetes mellitus (DM) patients, vaccinated by GamCovidVac (Sputnik V).
Materials and Methods: The pilot observational prospective study included 30 males with type 2 diabetes mellitus (DM). The study continued from February 2021 till June 2021. The research design involved medical history analysis, glycated hemoglobin (HbA1c) tests, total testosterone level in blood measurement, semen analysis (sperm count test). Group comparison was performed by Wilcoxon Signed Ranks Test. The differences were considered statistically significant at p<0.05.
Results: After vaccination 19 patients (63%) demonstrated a temperature rise which lasted for 2 days; 26 patients (87%) complained of tenderness in the injections site which lasted up to 5 days. Though a few patients reported general somatic side effects after the vaccination, there have been no statistically significant deviations in sperm count, viability, function and morphology. The levels of glycated hemoglobin and total testosterone remained unchanged.
Conclusion: The study revealed no negative impact of GamCovidVac on ejaculate quality, total testosterone level and compensation of carbohydrate metabolism.
About the Authors
D. I. Esaulenko
Voronezh state medical university named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Dmitry I. Esaulenko - MD, PhD; eLibrary SPIN: 2983-7767.
185 Dm. Moscow prospect, 394036 Voronezh
Competing Interests:
not
R. R. Rozhivanov
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Roman V. Rozhivanov - MD, PhD; eLibrary SPIN: 8052-3310.
11 Dm. Ulyanova street, 117036 Moscow
Competing Interests:
not
V. V. Shishkina
Voronezh state medical university named after N.N. Burdenko
Russian Federation
Competing Interests:
Russian Federation
Viktoria V. Shishkina - MD, PhD; eLibrary SPIN: 9339-7794.
185 Dm. Moscow prospect, 394036 Voronezh
Competing Interests:
not
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For citations:
Esaulenko D.I., Rozhivanov R.R., Shishkina V.V. Quality of ejaculate of male patients with type 2 diabetes mellitus (DM), vaccinated with GamCovidVac (Sputnik V). Diabetes mellitus. 2021;24(5):422-426. (In Russ.) https://doi.org/10.14341/DM12775
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