Endothelial progenitor cells in diabetes complications

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Abstract


Patients with diabetes mellitus (DM) have a 2- to 4-times higher risk of developing cardiovascular complications compared with non-diabetic controls. Hyperglycemia activates pathophysiological mechanisms that damage the endothelium. According to the current views, circulating progenitor cells derived from bone marrow repair the damage. These cells, known as endothelial progenitor cells (EPCs), maintain endothelial homeostasis and contribute to the formation of new vessels. Many clinical studies have reported that EPC population is dysfunctional and declines in numbers in patients with type 1 and type 2 DM. In addition, bone marrow doesn?t respond adequately to mobilizing stimuli in DM. Therefore, EPC alterations might have a pathogenic role in the complications of DM. In this review, EPC alterations will be examined in the context of macrovascular and microvascular complications of DM, highlighting their roles and functions in the progression of the disease.

Marina Cergeevna Michurova

Endocrinology Research Centre, Moscow

Author for correspondence.
Email: michurovams@gmail.com

Russian Federation PhD student

Victor Yur'evich Kalashnikov

Endocrinology Research Centre, Moscow

Email: Victor9368@gmail.com

Russian Federation MD, PhD, Head of the Emergency and Interventional Cardiology Department

Olga Michailovna Smirnova

Endocrinology Research Centre, Moscow

Email: Dr_smr@mail.ru

Russian Federation MD, PhD, Professor, Chief Researcher in Program Education and Treatment Department in Diabetes Institute.

Irina Vladimirovna Kononenko

Endocrinology Research Centre, Moscow

Email: Shakhtarina@bk.ru

Russian Federation MD, PhD, Leading Researcher in Program Education and Treatment Department in Diabetes Institute.

Olga Nikolaevna Ivanova

Endocrinology Research Centre, Moscow

Email: Genetics2@yandex.ru

Russian Federation PhD, senior staff scientist, Laboratory of Genetics and Clinical Immunology

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