Ileal transposition in surgical treatment for type 2 diabetes mellitus

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Abstract


High prevalence and insufficient efficacy of medical treatment in type 2 diabetes mellitus (T2DM) poses a major challenge for medical care. Generally, only 30% of patients reach therapeutic goals, while remission occurs only in the minority of patients. In the obese (BMI>35 kg/m2), bariatric surgery provides an alternative to pharmacological treatment of T2DM, boosting remission/compensation rate up to 76.8%. A few recent clinical studies explored the anti-diabetic effect of ileal transposition (IT). This type of surgery targets restoration of incretin balance by proximal transposition of ileal segment. In this review, we discuss the salutary mechanisms of IT in T2DM based on the analysis of the pioneering clinical trials.

Oleg Viktorovich Kornyushin

North-West Federal Medical Research Centre, St-Petersburg; First Pavlov State Medical University of St. Peterburg

Email: kornyushin@pochta.ru

Russian Federation MD, PhD, Cheif researcher

Mikhail Michailovich Galagudza

North-West Federal Medical Research Centre, St-Petersburg; First Pavlov State Medical University of St. Peterburg

Email: galagoudza@mail.ru

Russian Federation MD, PhD, Professor

Alexander Evgen'evich Neymark

North-West Federal Medical Research Centre, St-Petersburg; First Pavlov State Medical University of St. Peterburg

Email: sas_spb@mail.ru

Russian Federation MD, PhD, Cheif researcher

Alina Yur'evna Grineva

North-West Federal Medical Research Centre, St-Petersburg; First Pavlov State Medical University of St. Peterburg

Author for correspondence.
Email: alina_babenki@mail.ru

Russian Federation MD, PhD, Professor

Elena Nikolaevna Babenko

North-West Federal Medical Research Centre, St-Petersburg; First Pavlov State Medical University of St. Peterburg

Email: elena_grineva@mail.ru

Russian Federation MD, PhD

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Copyright (c) 2015 Kornyushin O.V., Galagudza M.M., Neymark A.E., Grineva A.Y., Babenko E.N.

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